An NMR study of the rates of single-molecule exchange in a cylindrical host capsule.

Published

Journal Article

Self-assembled cylindrical capsule 1 is reversibly formed from dimerization of two tetraimide resorcinarenes. Studies of guest exchange involving host capsule 1 reveal a mechanistic continuum for exchange that depends on the structure of the guest. Kinetic and dynamic NMR measurements demonstrate the direct displacement of one guest by another. Surprisingly, in the case of benzene exchange in the pairwise encapsulation of benzene and p-xylene, the incoming benzene occupies the same half of the capsule as the outgoing benzene. As the size of the guests increases, solvent-bridged intermediates determine the rates; empty volumes on the molecular scale need not be invoked.

Full Text

Duke Authors

Cited Authors

  • Craig, SL; Lin, S; Chen, J; Rebek, J

Published Date

  • July 2002

Published In

Volume / Issue

  • 124 / 30

Start / End Page

  • 8780 - 8781

PubMed ID

  • 12137515

Pubmed Central ID

  • 12137515

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja025672z

Language

  • eng