Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule
Publication
, Journal Article
Hof, F; Nuckolls, C; Craig, SL; Martin, T; Rebek, J
Published in: Journal of the American Chemical Society
November 8, 2000
Herein we report the synthesis of a molecule that self-organizes through hydrogen bonds into discrete tetrameric capsular species, encapsulating large polycyclic guest molecules. The unique folded structure of the assembled state is determined by correlation spectroscopy in conjunction with molecular modeling. Pendant methoxyl groups are essential for the assembly process and convey their influence through both electronic pathways and surface interactions. Spin polarization transfer experiments show that the capsule undergoes rapid guest-exchange processes while being itself kinetically stable at elevated temperatures.
Duke Scholars
Published In
Journal of the American Chemical Society
DOI
ISSN
0002-7863
Publication Date
November 8, 2000
Volume
122
Issue
44
Start / End Page
10991 / 10996
Related Subject Headings
- General Chemistry
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Hof, F., Nuckolls, C., Craig, S. L., Martin, T., & Rebek, J. (2000). Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule. Journal of the American Chemical Society, 122(44), 10991–10996. https://doi.org/10.1021/ja002340q
Hof, F., C. Nuckolls, S. L. Craig, T. Martin, and J. Rebek. “Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule.” Journal of the American Chemical Society 122, no. 44 (November 8, 2000): 10991–96. https://doi.org/10.1021/ja002340q.
Hof F, Nuckolls C, Craig SL, Martin T, Rebek J. Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule. Journal of the American Chemical Society. 2000 Nov 8;122(44):10991–6.
Hof, F., et al. “Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule.” Journal of the American Chemical Society, vol. 122, no. 44, Nov. 2000, pp. 10991–96. Scopus, doi:10.1021/ja002340q.
Hof F, Nuckolls C, Craig SL, Martin T, Rebek J. Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule. Journal of the American Chemical Society. 2000 Nov 8;122(44):10991–10996.
Published In
Journal of the American Chemical Society
DOI
ISSN
0002-7863
Publication Date
November 8, 2000
Volume
122
Issue
44
Start / End Page
10991 / 10996
Related Subject Headings
- General Chemistry
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences