Guest exchange in an encapsulation complex: a supramolecular substitution reaction.

Journal Article (Journal Article)

Encapsulation complexes are reversibly formed assemblies in which small molecule guests are completely surrounded by large molecule hosts. The assemblies are held together by weak intermolecular forces and are dynamic: they form and dissipate on time scales ranging from milliseconds to days-long enough for many interactions, even reactions, to take place within them. Little information is available on the exchange process, how guests get in and out of these complexes. Here we report that these events can be slow enough for conventional kinetic studies, and reactive intermediates can be detected. Guest exchange has much in common with familiar chemical substitution reactions, but differs in some respects: no covalent bonds are made or broken, the substrate is an assembly rather than a single molecule, and at least four molecules are involved in multiple rate-determining steps.

Full Text

Duke Authors

Cited Authors

  • Santamaría, J; Martín, T; Hilmersson, G; Craig, SL; Rebek, J

Published Date

  • July 1999

Published In

Volume / Issue

  • 96 / 15

Start / End Page

  • 8344 - 8347

PubMed ID

  • 10411877

Pubmed Central ID

  • PMC17519

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.96.15.8344


  • eng