Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.
Publication
, Journal Article
McDonnell, DP; Connor, CE; Wijayaratne, A; Chang, C-Y; Norris, JD
Published in: Recent Prog Horm Res
2002
The term selective estrogen receptor modulators describes a group of pharmaceuticals that function as estrogen receptor (ER) agonists in some tissues but that oppose estrogen action in others. Although the name for this class of drugs has been adopted only recently, the concept is not new, as compounds exhibiting tissue-selective ER agonist/antagonist properties have been around for nearly 40 years. What is new is the idea that it may be possible to capitalize on the paradoxical activities of these drugs and develop them as target organ-selective ER agonists for the treatment of osteoporosis and other estrogenopathies. This realization has provided the impetus for research in this area, the progress of which is discussed in this review.
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Published In
Recent Prog Horm Res
DOI
ISSN
0079-9963
Publication Date
2002
Volume
57
Start / End Page
295 / 316
Location
United States
Related Subject Headings
- Tamoxifen
- Structure-Activity Relationship
- Selective Estrogen Receptor Modulators
- Receptors, Estrogen
- Protein Conformation
- Humans
- Female
- Estrogen Receptor beta
- Estrogen Antagonists
- Endocrinology & Metabolism
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McDonnell, D. P., Connor, C. E., Wijayaratne, A., Chang, C.-Y., & Norris, J. D. (2002). Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Prog Horm Res, 57, 295–316. https://doi.org/10.1210/rp.57.1.295
McDonnell, Donald P., Caroline E. Connor, Ashini Wijayaratne, Ching-Yi Chang, and John D. Norris. “Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.” Recent Prog Horm Res 57 (2002): 295–316. https://doi.org/10.1210/rp.57.1.295.
McDonnell DP, Connor CE, Wijayaratne A, Chang C-Y, Norris JD. Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Prog Horm Res. 2002;57:295–316.
McDonnell, Donald P., et al. “Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.” Recent Prog Horm Res, vol. 57, 2002, pp. 295–316. Pubmed, doi:10.1210/rp.57.1.295.
McDonnell DP, Connor CE, Wijayaratne A, Chang C-Y, Norris JD. Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Prog Horm Res. 2002;57:295–316.
Published In
Recent Prog Horm Res
DOI
ISSN
0079-9963
Publication Date
2002
Volume
57
Start / End Page
295 / 316
Location
United States
Related Subject Headings
- Tamoxifen
- Structure-Activity Relationship
- Selective Estrogen Receptor Modulators
- Receptors, Estrogen
- Protein Conformation
- Humans
- Female
- Estrogen Receptor beta
- Estrogen Antagonists
- Endocrinology & Metabolism