Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.

Journal Article (Journal Article;Review)

The term selective estrogen receptor modulators describes a group of pharmaceuticals that function as estrogen receptor (ER) agonists in some tissues but that oppose estrogen action in others. Although the name for this class of drugs has been adopted only recently, the concept is not new, as compounds exhibiting tissue-selective ER agonist/antagonist properties have been around for nearly 40 years. What is new is the idea that it may be possible to capitalize on the paradoxical activities of these drugs and develop them as target organ-selective ER agonists for the treatment of osteoporosis and other estrogenopathies. This realization has provided the impetus for research in this area, the progress of which is discussed in this review.

Full Text

Duke Authors

Cited Authors

  • McDonnell, DP; Connor, CE; Wijayaratne, A; Chang, C-Y; Norris, JD

Published Date

  • 2002

Published In

Volume / Issue

  • 57 /

Start / End Page

  • 295 - 316

PubMed ID

  • 12017549

International Standard Serial Number (ISSN)

  • 0079-9963

Digital Object Identifier (DOI)

  • 10.1210/rp.57.1.295


  • eng

Conference Location

  • United States