Hunger selectively modulates corticolimbic activation to food stimuli in humans.

Published

Journal Article

Functional magnetic resonance imaging (fMRI) was used to determine whether visual responses to food in the human amygdala and related corticolimbic structures would be selectively altered by changes in states of hunger. Participants viewed images of motivationally relevant (food) and motivationally irrelevant (tool) objects while undergoing fMRI in alternately hungry and satiated conditions. Food-related visual stimuli elicited greater responses in the amygdala, parahippocampal gyrus. and anterior fusiform gyrus when participants were in a hungry state relative to a satiated state. The state-dependent activation of these brain structures did not generalize to the motivationally irrelevant objects. These results support the hypothesis that the amygdala and associated inferotemporal regions are involved in the integration of subjective interoceptive states with relevant sensory cues processed along the ventral visual stream.

Full Text

Duke Authors

Cited Authors

  • LaBar, KS; Gitelman, DR; Parrish, TB; Kim, YH; Nobre, AC; Mesulam, MM

Published Date

  • April 2001

Published In

Volume / Issue

  • 115 / 2

Start / End Page

  • 493 - 500

PubMed ID

  • 11345973

Pubmed Central ID

  • 11345973

Electronic International Standard Serial Number (EISSN)

  • 1939-0084

International Standard Serial Number (ISSN)

  • 0735-7044

Digital Object Identifier (DOI)

  • 10.1037//0735-7044.115.2.493

Language

  • eng