Impaired fear conditioning following unilateral temporal lobectomy in humans.

Journal Article (Journal Article)

Classical fear conditioning was used in the present study as a model for investigating emotional learning and memory in human subjects with lesions to the medial temporal lobe. Animal studies have revealed a critical role for medial temporal lobe structures, particularly the amygdala, in simple and complex associative emotional responding. Whether these structures perform similar functions in humans is unknown. On both simple and conditional discrimination tasks, unilateral temporal lobectomy subjects showed impaired conditioned response acquisition relative to control subjects. This impairment could not be accounted for by deficits in nonassociative sensory or autonomic performance factors, or by differences in declarative memory for the experimental parameters. These results show that temporal lobe structures in humans, as in other mammals, are important components in an emotional memory network.

Full Text

Duke Authors

Cited Authors

  • LaBar, KS; LeDoux, JE; Spencer, DD; Phelps, EA

Published Date

  • October 1995

Published In

Volume / Issue

  • 15 / 10

Start / End Page

  • 6846 - 6855

PubMed ID

  • 7472442

Pubmed Central ID

  • PMC6578018

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.15-10-06846.1995


  • eng