Brain regions differentially involved in remembering what and when: a PET study.

Journal Article (Journal Article)

Recollecting a past episode involves remembering not only what happened but also when it happened. We used positron emission tomography (PET) to directly contrast the neural correlates of item and temporalorder memory. Subjects studied a list of words and were then scanned while retrieving information about what words were in the list or when they occurred within the list. Item retrieval was related to increased neural activity in medial temporal and basal forebrain regions, whereas temporal-order retrieval was associated with activations in dorsal prefrontal, cuneus/precuneus, and right posterior parietal regions. The dissociation between temporal and frontal lobe regions confirms and extends previous lesion data. The results show that temporal-order retrieval involves a network of frontal and posterior brain regions.

Full Text

Duke Authors

Cited Authors

  • Cabeza, R; Mangels, J; Nyberg, L; Habib, R; Houle, S; McIntosh, AR; Tulving, E

Published Date

  • October 1997

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 863 - 870

PubMed ID

  • 9354332

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(00)80967-8


  • eng