Animal models for schizophrenia: the hippocampally lesioned animal.


Journal Article

Animals with hippocampal lesions are evaluated as models for schizophrenia according to the criteria of McKinney and Bunney (1969). They seem to comply adequately with the following requirements: similarity of inducing conditions; similarity of behavioral states; similarity of underlying neurobiological mechanisms; and reversibility by usual pharmacological treatment. The model seems adequate to reproduce several symptoms of the disorder, offering a good experimental tool for the analysis of its inducing conditions, affected neurobiological mechanisms, and clinical treatment.

Full Text

Cited Authors

  • Schmajuk, NA

Published Date

  • January 1987

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 317 - 327

PubMed ID

  • 3616522

Pubmed Central ID

  • 3616522

Electronic International Standard Serial Number (EISSN)

  • 1745-1701

International Standard Serial Number (ISSN)

  • 1787-9965

Digital Object Identifier (DOI)

  • 10.1093/schbul/13.2.317


  • eng