Inhibitory and excitatory mechanisms underlying auditory responses to learned vocalizations in the songbird nucleus HVC.

Published

Journal Article

Speech and birdsong require auditory feedback for their development and maintenance, necessitating precise auditory encoding of vocal sounds. In songbirds, the telencephalic song premotor nucleus HVC contains neurons that respond highly selectively to the bird's own song (BOS), a property distinguishing HVC from its auditory afferents. We examined the contribution of inhibitory and excitatory synaptic inputs to BOS-evoked firing in those HVC neurons innervating a pathway essential for audition-dependent vocal plasticity. Using in vivo intracellular techniques, we found that G protein-coupled, potassium-mediated inhibition, tuned to the BOS, interacts with BOS-tuned excitation through several mechanisms to shape neuronal firing patterns. Furthermore, in the absence of this inhibition, the response bias to the BOS increases, reminiscent of cancellation mechanisms in other sensorimotor systems.

Full Text

Duke Authors

Cited Authors

  • Rosen, MJ; Mooney, R

Published Date

  • July 3, 2003

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 177 - 194

PubMed ID

  • 12848941

Pubmed Central ID

  • 12848941

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(03)00357-x

Language

  • eng

Conference Location

  • United States