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Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study.

Publication ,  Journal Article
LaBar, KS; Gatenby, JC; Gore, JC; LeDoux, JE; Phelps, EA
Published in: Neuron
May 1998

Echoplanar functional magnetic resonance imaging (fMRI) was used in normal human subjects to investigate the role of the amygdala in conditioned fear acquisition and extinction. A simple discrimination procedure was employed in which activation to a visual cue predicting shock (CS+) was compared with activation to another cue presented alone (CS-). CS+ and CS- trial types were intermixed in a pseudorandom order. Functional images were acquired with an asymmetric spin echo pulse sequence from three coronal slices centered on the amygdala. Activation of the amygdala/periamygdaloid cortex was observed during conditioned fear acquisition and extinction. The extent of activation during acquisition was significantly correlated with autonomic indices of conditioning in individual subjects. Consistent with a recent electrophysiological recording study in the rat (Quirk et al., 1997), the profile of the amygdala response was temporally graded, although this dynamic was only statistically reliable during extinction. These results provide further evidence for the conservation of amygdala function across species and implicate an amygdalar contribution to both acquisition and extinction processes during associative emotional learning tasks.

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Published In

Neuron

DOI

EISSN

1097-4199

ISSN

0896-6273

Publication Date

May 1998

Volume

20

Issue

5

Start / End Page

937 / 945

Related Subject Headings

  • Regression Analysis
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Fear
  • Extinction, Psychological
  • Conditioning, Psychological
  • Association Learning
 

Citation

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ICMJE
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LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998). Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron, 20(5), 937–945. https://doi.org/10.1016/s0896-6273(00)80475-4
LaBar, K. S., J. C. Gatenby, J. C. Gore, J. E. LeDoux, and E. A. Phelps. “Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study.Neuron 20, no. 5 (May 1998): 937–45. https://doi.org/10.1016/s0896-6273(00)80475-4.
LaBar KS, Gatenby JC, Gore JC, LeDoux JE, Phelps EA. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron. 1998 May;20(5):937–45.
LaBar, K. S., et al. “Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study.Neuron, vol. 20, no. 5, May 1998, pp. 937–45. Epmc, doi:10.1016/s0896-6273(00)80475-4.
LaBar KS, Gatenby JC, Gore JC, LeDoux JE, Phelps EA. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron. 1998 May;20(5):937–945.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

ISSN

0896-6273

Publication Date

May 1998

Volume

20

Issue

5

Start / End Page

937 / 945

Related Subject Headings

  • Regression Analysis
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Fear
  • Extinction, Psychological
  • Conditioning, Psychological
  • Association Learning