Faces evoke spatially differentiated patterns of BOLD activation and deactivation.


Journal Article

Using fMRI techniques sensitive to blood oxygen-level dependent (BOLD) contrast, we measured brain activity in participants (n=8) as they viewed images of faces presented periodically within a continuously changing montage of common objects. Consistent with prior studies, we identified regions of ventral extrastriate cortex, primarily in the fusiform and inferior temporal gyri and nearby cortex, that were activated by faces as measured by an increase in BOLD signal. In addition, we made the novel observation that faces deactivated other areas of ventral extrastriate cortex, primarily in the lingual and parahippocampal gyri and medial to activations. These deactivated regions, identified by a decrease in BOLD signal, may reflect populations of neurons that decrease their activity when faces appear, possibly as a consequence of category-specific inhibition.

Full Text

Duke Authors

Cited Authors

  • Pelphrey, KA; Mack, PB; Song, A; Güzeldere, G; McCarthy, G

Published Date

  • May 23, 2003

Published In

Volume / Issue

  • 14 / 7

Start / End Page

  • 955 - 959

PubMed ID

  • 12802182

Pubmed Central ID

  • 12802182

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/01.wnr.0000074345.81633.ad


  • eng

Conference Location

  • England