A morphological basis for orientation tuning in primary visual cortex.

Journal Article (Journal Article)

Feedforward connections are thought to be important in the generation of orientation-selective responses in visual cortex by establishing a bias in the sampling of information from regions of visual space that lie along a neuron's axis of preferred orientation. It remains unclear, however, which structural elements-dendrites or axons-are ultimately responsible for conveying this sampling bias. To explore this question, we have examined the spatial arrangement of feedforward axonal connections that link non-oriented neurons in layer 4 and orientation-selective neurons in layer 2/3 of visual cortex in the tree shrew. Target sites of labeled boutons in layer 2/3 resulting from focal injections of biocytin in layer 4 show an orientation-specific axial bias that is sufficient to confer orientation tuning to layer 2/3 neurons. We conclude that the anisotropic arrangement of axon terminals is the principal source of the orientation bias contributed by feedforward connections.

Full Text

Duke Authors

Cited Authors

  • Mooser, F; Bosking, WH; Fitzpatrick, D

Published Date

  • August 2004

Published In

Volume / Issue

  • 7 / 8

Start / End Page

  • 872 - 879

PubMed ID

  • 15258585

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn1287


  • eng

Conference Location

  • United States