Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory.

Journal Article (Journal Article)

Although research has demonstrated that short-term improvement in memory function of adult rats can occur when the availability of precursors for the neurotransmitter acetylcholine is increased, little is known about whether memory function of adult rats can be permanently altered by precursor supplementation during early development. In the present study, male albino rats were exposed to choline chloride supplementation both prenatally (through the diet of pregnant rats) and postnatally (subcutaneous injections). At 60 days of age rats were tested on a 12- and 18-arm radial maze task. Results indicated that compared to control littermates, perinatal choline-treated rats showed more accurate performance on both working and reference memory components of the task. This performance difference was apparent on the first block of sessions and continued throughout training. Further analysis revealed that the difference between choline and control rats is not due to use of differential response or cue-use strategies. Instead, it appears that choline induced performance differences are due to long-term enhancement of spatial memory capacity and precision.

Full Text

Duke Authors

Cited Authors

  • Meck, WH; Smith, RA; Williams, CL

Published Date

  • May 1988

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 339 - 353

PubMed ID

  • 3378679

Electronic International Standard Serial Number (EISSN)

  • 1098-2302

International Standard Serial Number (ISSN)

  • 0012-1630

Digital Object Identifier (DOI)

  • 10.1002/dev.420210405


  • eng