A new millenium for spinal cord regeneration: growth-associated genes.


Journal Article (Review)

INTRODUCTION: Neurons surviving spinal cord injury undergo extensive reorganization that may result in the formation of functional synaptic contacts. Many neurons, however, fail to activate the necessary mechanisms for successful regeneration. In this review, we discuss the implications of growth cone genes that we have correlated with successful spinal cord axonal regeneration. METHOD: Factors that inhibit regeneration, and activation of genes that promote it are discussed. RESULTS/DISCUSSION: The early progress n understanding mechanisms that seem to promote or inhibit regeneration in the central nervous system may have significant clinical utility in the future.

Full Text

Duke Authors

Cited Authors

  • Bulsara, KR; Iskandar, BJ; Villavicencio, AT; Skene, JHP

Published Date

  • September 1, 2002

Published In

Volume / Issue

  • 27 / 17

Start / End Page

  • 1946 - 1949

PubMed ID

  • 12221366

Pubmed Central ID

  • 12221366

Electronic International Standard Serial Number (EISSN)

  • 1528-1159

Digital Object Identifier (DOI)

  • 10.1097/00007632-200209010-00030


  • eng

Conference Location

  • United States