Transcriptional regulation and the evolution of development.

Published

Journal Article (Review)

A growing body of evidence suggests that changes in transcriptional regulation form an important part of the genetic basis for the evolution of development. At a microevolutionary level, all the necessary conditions are present: populations harbor abundant genetic variation for differences in transcription profiles, a substantial fraction of these variants can influence organismal phenotype, and some variants have fitness consequences and are subject to natural selection. At a macroevolutionary level, the evidence is less direct but strongly suggestive: specific differences in anatomy and gene expression are often correlated, while comparisons of transcription profiles among distantly related taxa point to extensive evolutionary changes in regulatory gene networks. Understanding how transcriptional regulatory systems evolve, and what contributions these changes have made to the evolution of phenotype, represents a major challenge for Evo-Devo.

Full Text

Duke Authors

Cited Authors

  • Wray, GA

Published Date

  • January 2003

Published In

Volume / Issue

  • 47 / 7-8

Start / End Page

  • 675 - 684

PubMed ID

  • 14756343

Pubmed Central ID

  • 14756343

Electronic International Standard Serial Number (EISSN)

  • 1696-3547

International Standard Serial Number (ISSN)

  • 0214-6282

Language

  • eng