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Transcriptional regulation and the evolution of development.

Publication ,  Journal Article
Wray, GA
Published in: The International journal of developmental biology
January 2003

A growing body of evidence suggests that changes in transcriptional regulation form an important part of the genetic basis for the evolution of development. At a microevolutionary level, all the necessary conditions are present: populations harbor abundant genetic variation for differences in transcription profiles, a substantial fraction of these variants can influence organismal phenotype, and some variants have fitness consequences and are subject to natural selection. At a macroevolutionary level, the evidence is less direct but strongly suggestive: specific differences in anatomy and gene expression are often correlated, while comparisons of transcription profiles among distantly related taxa point to extensive evolutionary changes in regulatory gene networks. Understanding how transcriptional regulatory systems evolve, and what contributions these changes have made to the evolution of phenotype, represents a major challenge for Evo-Devo.

Duke Scholars

Published In

The International journal of developmental biology

EISSN

1696-3547

ISSN

0214-6282

Publication Date

January 2003

Volume

47

Issue

7-8

Start / End Page

675 / 684

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Species Specificity
  • Selection, Genetic
  • Regulatory Sequences, Nucleic Acid
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Mutation
  • Genetics, Population
  • Genes, Homeobox
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wray, G. A. (2003). Transcriptional regulation and the evolution of development. The International Journal of Developmental Biology, 47(7–8), 675–684.
Wray, Gregory A. “Transcriptional regulation and the evolution of development.The International Journal of Developmental Biology 47, no. 7–8 (January 2003): 675–84.
Wray GA. Transcriptional regulation and the evolution of development. The International journal of developmental biology. 2003 Jan;47(7–8):675–84.
Wray, Gregory A. “Transcriptional regulation and the evolution of development.The International Journal of Developmental Biology, vol. 47, no. 7–8, Jan. 2003, pp. 675–84.
Wray GA. Transcriptional regulation and the evolution of development. The International journal of developmental biology. 2003 Jan;47(7–8):675–684.

Published In

The International journal of developmental biology

EISSN

1696-3547

ISSN

0214-6282

Publication Date

January 2003

Volume

47

Issue

7-8

Start / End Page

675 / 684

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Species Specificity
  • Selection, Genetic
  • Regulatory Sequences, Nucleic Acid
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Mutation
  • Genetics, Population
  • Genes, Homeobox