Molecular mechanisms of copper uptake and distribution.


Journal Article (Review)

In the past few years, exciting advances have been made toward understanding how copper is transported into and distributed to cupro-proteins within cells. Recent work has identified high-affinity copper transporters at the plasma membrane in a number of organisms. The elucidation of the three-dimensional structure of copper chaperones and target cupro-proteins has shown that highly specific interactions between homologous domains foster copper transfer between conserved copper ligands, and facilitate a detailed understanding of vectorial copper-transfer reactions. Furthermore, the recent generation of mouse-knockout models, deficient in a high-affinity copper transporter, or in copper chaperones, has demonstrated the importance of copper uptake and targeted distribution in both predicted and fascinating unanticipated ways in growth and development.

Full Text

Cited Authors

  • Puig, S; Thiele, DJ

Published Date

  • April 2002

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 171 - 180

PubMed ID

  • 12039001

Pubmed Central ID

  • 12039001

Electronic International Standard Serial Number (EISSN)

  • 1879-0402

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(02)00298-3


  • eng