How does calcium trigger neurotransmitter release?


Journal Article (Review)

Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.

Full Text

Cited Authors

  • Augustine, GJ

Published Date

  • June 2001

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 320 - 326

PubMed ID

  • 11399430

Pubmed Central ID

  • 11399430

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

International Standard Serial Number (ISSN)

  • 0959-4388

Digital Object Identifier (DOI)

  • 10.1016/s0959-4388(00)00214-2


  • eng