Proteins involved in synaptic vesicle trafficking.


Journal Article (Review)

Neurotransmitter release relies on a series of synaptic vesicle trafficking reactions. We have determined the molecular basis of these reactions by microinjecting, into 'giant' nerve terminals of squid, probes that interfere with presynaptic proteins. These probes affect neurotransmitter release and disrupt nerve terminal structure. From the nature of these lesions, it is possible to deduce the roles of individual proteins in specific vesicle trafficking reactions. This approach has revealed the function of more than a dozen presynaptic proteins and we hypothesize that neurotransmitter release requires the coordinated action of perhaps 50-100 proteins.

Full Text

Cited Authors

  • Augustine, GJ; Burns, ME; DeBello, WM; Hilfiker, S; Morgan, JR; Schweizer, FE; Tokumaru, H; Umayahara, K

Published Date

  • October 1999

Published In

Volume / Issue

  • 520 Pt 1 /

Start / End Page

  • 33 - 41

PubMed ID

  • 10517798

Pubmed Central ID

  • 10517798

Electronic International Standard Serial Number (EISSN)

  • 1469-7793

International Standard Serial Number (ISSN)

  • 0022-3751

Digital Object Identifier (DOI)

  • 10.1111/j.1469-7793.1999.00033.x


  • eng