Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice.


Journal Article

Weaver mice carry a mutation in the pore domain of the Girk2 (Kcnj6) gene. The mutation causes GIRK2 containing channels to lose ion selectivity and to become constitutively active. It is not known how this alteration in ion channel activity causes in cerebellar granule cells the defects in neurite extension, cell migration and induction of cell death that are characteristic of weaver mice. One possibility is that the mutation causes an inability to regulate intracellular calcium levels properly. We tested this hypothesis by measuring intracellular calcium levels in granule cells and Purkinje cells in slices from the cerebellum of weaver mice. We report here that weaver mice have increases in resting calcium levels in their granule cells, which may account for the multiple effects of the weaver mutation upon these cells.

Full Text

Cited Authors

  • Womack, M; Thompson, K; Fanselow, E; Augustine, GJ; Peterson, A

Published Date

  • October 1998

Published In

Volume / Issue

  • 9 / 15

Start / End Page

  • 3391 - 3395

PubMed ID

  • 9855287

Pubmed Central ID

  • 9855287

Electronic International Standard Serial Number (EISSN)

  • 1473-558X

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199810260-00011


  • eng