Distribution of functional glutamate and GABA receptors on hippocampal pyramidal cells and interneurons.


Journal Article

The distribution of functional neurotransmitter receptors is an important determinant of neuronal information processing. To map the location of functional glutamate and GABA receptors on individual hippocampal neurons, we photolyzed "caged" glutamate and GABA while measuring the electrical currents resulting from activation of these receptors. Responses to uncaged neurotransmitters were spatially nonuniform and varied according to the type of receptor and type of neuron. Every region of CA1 pyramidal cells responded to glutamate and GABA, but glutamate and GABA receptors increased in density along the length of their distal dendrites. Similar gradients of glutamate receptors were found in stratum radiatum interneurons, while GABA responses were detectable only in the perisomatic region of these interneurons. These regional variations in receptor distribution indicate the selective targeting of receptors on central neurons and may reflect a mechanism for local regulation of synaptic efficacy.

Full Text

Cited Authors

  • Pettit, DL; Augustine, GJ

Published Date

  • July 2000

Published In

Volume / Issue

  • 84 / 1

Start / End Page

  • 28 - 38

PubMed ID

  • 10899180

Pubmed Central ID

  • 10899180

Electronic International Standard Serial Number (EISSN)

  • 1522-1598

International Standard Serial Number (ISSN)

  • 0022-3077

Digital Object Identifier (DOI)

  • 10.1152/jn.2000.84.1.28


  • eng