Local calcium signaling in neurons.


Journal Article (Review)

Transient rises in the cytoplasmic concentration of calcium ions serve as second messenger signals that control many neuronal functions. Selective triggering of these functions is achieved through spatial localization of calcium signals. Several qualitatively different forms of local calcium signaling can be distinguished by the location of open calcium channels as well as by the distance between these channels and the calcium binding proteins that serve as the molecular targets of calcium action. Local calcium signaling is especially prominent at presynaptic active zones and postsynaptic densities, structures that are distinguished by highly organized macromolecular arrays that yield precise spatial arrangements of calcium signaling proteins. Similar forms of local calcium signaling may be employed throughout the nervous system, though much remains to be learned about the molecular underpinnings of these events.

Full Text

Cited Authors

  • Augustine, GJ; Santamaria, F; Tanaka, K

Published Date

  • October 1, 2003

Published In

Volume / Issue

  • 40 / 2

Start / End Page

  • 331 - 346

PubMed ID

  • 14556712

Pubmed Central ID

  • 14556712

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(03)00639-1


  • eng