Instructive roles of neurotrophins in synaptic plasticity.


Journal Article (Review)

Together, these experiments show that neurotrophins regulate neuronal function in a factor-dependent fashion, both in terms of membrane excitability and dendritic growth, and indicate that neurotrophins can play instructive roles in regulating neuronal phenotype and function. Given that neurons generally receive neurotrophic inputs from many different cellular sources, both regional and distant (e.g., via axonal and dendritic projections), instructive actions of neurotrophic factors may contribute to matching the morphology and electrical function of neurons to the neural circuits of which they are part. Moreover, during ongoing development and function of the nervous system, these same or similar neurotrophic factors may be key instructive signals in regulating synaptic plasticity of neural circuits.

Full Text

Cited Authors

  • Lo, DC

Published Date

  • January 1998

Published In

Volume / Issue

  • 117 /

Start / End Page

  • 65 - 70

PubMed ID

  • 9932401

Pubmed Central ID

  • 9932401

Electronic International Standard Serial Number (EISSN)

  • 1875-7855

International Standard Serial Number (ISSN)

  • 0079-6123

Digital Object Identifier (DOI)

  • 10.1016/s0079-6123(08)64008-x


  • eng