Neurotrophin regulation of cortical dendritic growth requires activity.


Journal Article

Neurotrophins have been proposed to mediate several forms of activity-dependent competition in the central nervous system. A key element of such hypotheses is that neurotrophins act preferentially on active neurons; however, little direct evidence supports this postulate. We therefore examined, in ferret cortical brain slices, the interactions between activity and neurotrophins in regulating dendritic growth of layer 4 pyramidal neurons. Inhibition of spontaneous electrical activity, synaptic transmission, or L-type calcium channels each prevented the otherwise dramatic increase in dendritic arborizations elicited by brain-derived neurotrophic factor. In developing cortex, this requirement for conjoint neurotrophin signaling and activity provides a mechanism for selectively enhancing the growth and connectivity of active neurons.

Full Text

Cited Authors

  • McAllister, AK; Katz, LC; Lo, DC

Published Date

  • December 1996

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 1057 - 1064

PubMed ID

  • 8982155

Pubmed Central ID

  • 8982155

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(00)80239-1


  • eng