Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth.


Journal Article

Neurotrophin regulation of neuronal morphology is complex and may involve differential action of alternative Trk receptor isoforms. We transfected ferret visual cortical slices with full-length and truncated TrkB receptors to examine their roles in regulating cortical dendrite development. These TrkB isoforms had differential effects on dendritic arborization: whereas full-length TrkB increased proximal dendritic branching, truncated TrkB promoted net elongation of distal dendrites. The morphological effects of each receptor isoform were distinct, yet their actions inhibited one another. Actions of the truncated TrkB receptor did not involve unmasking of endogenous TrkC signaling. These results suggest that TrkB receptors do not regulate dendritic growth per se but, rather, the mode of such growth.

Full Text

Cited Authors

  • Yacoubian, TA; Lo, DC

Published Date

  • April 2000

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 342 - 349

PubMed ID

  • 10725923

Pubmed Central ID

  • 10725923

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/73911


  • eng