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Neurotrophins differentially regulate voltage-gated ion channels.

Publication ,  Journal Article
Lesser, SS; Sherwood, NT; Lo, DC
Published in: Molecular and cellular neurosciences
January 1997

Neurotrophic factors profoundly affect neuronal differentiation, but whether they influence neuronal phenotype in instructive ways remains unclear: do different neurotrophic factors always trigger identical programs of differentiation or can each impose distinct functional properties even when acting upon the same population of target neurons? We addressed this issue by examining the regulatory effects of the four neurotrophins on the molecular components of electrical excitability, voltage-gated ion channels, within a single cellular context. Using patch clamp methods, we studied neurotrophin regulation of voltage-gated sodium, calcium, and potassium currents in SK-N-SH neuroblastoma cells. We found that each neurotrophin induced a unique pattern of expression of ionic currents despite similar activation of initial signal transduction events. Thus, each neurotrophin imposed a different excitable phenotype even when acting upon the same target cells.

Duke Scholars

Published In

Molecular and cellular neurosciences

DOI

EISSN

1095-9327

ISSN

1044-7431

Publication Date

January 1997

Volume

10

Issue

3-4

Start / End Page

173 / 183

Related Subject Headings

  • Tumor Cells, Cultured
  • Sodium Channels
  • Signal Transduction
  • Potassium Channels
  • Neurology & Neurosurgery
  • Neuroblastoma
  • Nerve Growth Factors
  • Ion Channels
  • Ion Channel Gating
  • Humans
 

Citation

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Lesser, S. S., Sherwood, N. T., & Lo, D. C. (1997). Neurotrophins differentially regulate voltage-gated ion channels. Molecular and Cellular Neurosciences, 10(3–4), 173–183. https://doi.org/10.1006/mcne.1997.0656
Lesser, S. S., N. T. Sherwood, and D. C. Lo. “Neurotrophins differentially regulate voltage-gated ion channels.Molecular and Cellular Neurosciences 10, no. 3–4 (January 1997): 173–83. https://doi.org/10.1006/mcne.1997.0656.
Lesser SS, Sherwood NT, Lo DC. Neurotrophins differentially regulate voltage-gated ion channels. Molecular and cellular neurosciences. 1997 Jan;10(3–4):173–83.
Lesser, S. S., et al. “Neurotrophins differentially regulate voltage-gated ion channels.Molecular and Cellular Neurosciences, vol. 10, no. 3–4, Jan. 1997, pp. 173–83. Epmc, doi:10.1006/mcne.1997.0656.
Lesser SS, Sherwood NT, Lo DC. Neurotrophins differentially regulate voltage-gated ion channels. Molecular and cellular neurosciences. 1997 Jan;10(3–4):173–183.
Journal cover image

Published In

Molecular and cellular neurosciences

DOI

EISSN

1095-9327

ISSN

1044-7431

Publication Date

January 1997

Volume

10

Issue

3-4

Start / End Page

173 / 183

Related Subject Headings

  • Tumor Cells, Cultured
  • Sodium Channels
  • Signal Transduction
  • Potassium Channels
  • Neurology & Neurosurgery
  • Neuroblastoma
  • Nerve Growth Factors
  • Ion Channels
  • Ion Channel Gating
  • Humans