Antibody responses in athymic ('nude') mice implanted with neonatal or adult allogeneic thymus

Journal Article

It has been reported that antibody forming capacity in athymic (nude) mice can be restored only by transplantation of thymus cells from histocompatible donors. In experiments reported, nude mice received, 4 wk prior to the injection of sheep erythrocytes, solid thymus grafts from neonatal or 3 wk old allogeneic donors. Restoration of antibody forming capacity and persistence of transplants at the graft site were observed in animals receiving neonatal but not in animals receiving 3 wk old thymus tissue.

Duke Authors

Cited Authors

  • McCann, RL; Sussdorf, DH

Published Date

  • 1974

Published In

  • Proceedings of the Society for Experimental Biology and Medicine

Volume / Issue

  • 145 / 2

Start / End Page

  • 351 - 353

PubMed ID

  • 4814133