Achilles tendon healing: a correlation between functional and mechanical performance in the rat.

Published

Journal Article

The pathogenesis and treatment of rupture of the Achilles tendon remain a source of controversy. This study presents the results of a biomechanical, functional, and morphological evaluation of a group of rats that had division and repair of the Achilles tendon. A total of 46 rats were used: 18 for biomechanical testing, 18 for functional evaluation, and 10 for histology. Morphological examination revealed an early inflammatory response with loose connective tissue formation that was replaced gradually by fibroblasts and a collagenous matrix. The functional evaluation (Achilles functional index [AFI]) was made from measurements of the hind pawprints of walking rats. Division and repair of the Achilles tendon produced a significant functional impairment (mean [+/- SEM] AFI = -87 +/- 8; p < 0.001), which gradually improved with healing time. The load to failure for the repaired tendons consistently improved with healing time, in a manner similar to the functional recovery. The average deformation (repair/control) varied considerably and was not related to healing time. The stiffness of the repaired tendons increased with healing time and was 60% of the corresponding control side by day 15. The major finding of this study was a strong correlation between the AFI and the failure load of the healing tendon-bone constructs (250-300 g group, r = 0.97, p < 0.001; 325-375 g group, r = 0.96, p < 0.001).

Full Text

Duke Authors

Cited Authors

  • Best, TM; Collins, A; Lilly, EG; Seaber, AV; Goldner, R; Murrell, GA

Published Date

  • November 1993

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 897 - 906

PubMed ID

  • 8283336

Pubmed Central ID

  • 8283336

Electronic International Standard Serial Number (EISSN)

  • 1554-527X

International Standard Serial Number (ISSN)

  • 0736-0266

Digital Object Identifier (DOI)

  • 10.1002/jor.1100110617

Language

  • eng