Relationship of age and menopausal status to estrogen receptor content in primary carcinoma of the breast.

Journal Article

The cytosolic estrogen receptor (CER) content of 1037 primary breast carcinomas was evaluated by sucrose density gradient analysis. Tumor specimens from premenopausal patients had significantly lower levels of CER (14.6 +/- 1.5 (mean +/- SEM) 8S binding fmole/mg protein) compared with carcinomas from postmenopausal patients (57.5 +/- 3.9 fmole/mg protein; p less than 0.001). The proportion of specimens with CER levels above threshold values of 3, 7, or 10 fmoles/mg protein were significantly higher for postmenopausal patients (72%, 63%, 59%, respectively) than for premenopausal patients (56%, 42%, 36%, p less than 0.001). When compared within half-decades, no statistically significant differences between premenopausal and postmenopausal patients were observed for mean, median, or rank sums of CER levels (p greater than 0.3). When patients were compared by half-decades, both mean and ranked sums of CER levels were significantly different (p less than 0.001). The proportion of specimens that demonstrated CER levels above a threshold value of 10 fmole/mg protein increased sequentially from a low of 13/51 (26%) for patients less than 35 years to a high of 60/81 (74%) for patients greater than 75 years.

Full Text

Duke Authors

Cited Authors

  • McCarty, KS; Silva, JS; Cox, EB; Leight, GS; Wells, SA; McCarty, KS

Published Date

  • February 1983

Published In

Volume / Issue

  • 197 / 2

Start / End Page

  • 123 - 127

PubMed ID

  • 6824366

International Standard Serial Number (ISSN)

  • 0003-4932

Language

  • eng

Conference Location

  • United States