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Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein.

Publication ,  Journal Article
Ingram, DL; Mossler, JA; Snowhite, J; Leight, GS; McCarty, KS
Published in: Arch Pathol Lab Med
November 1984

Granular cell tumors occur in a variety of sites, including the breast (6%). Origins from histiocytic, myogenic, fibroblastic, and neurogenic elements have been proposed. Female predominance suggests that estrogenic hormones are involved. Four granular cell tumors of the breast and one in an axillary lymph node were studied for sex steroid receptor content, myoglobin, carcinoembryonic antigen, and S100 protein localization. Antimyoglobin antibody did not localize in these tumors. Carcinoembryonic antigen and S100 protein localized in the cytoplasm of these tumors. Neither estrogen nor progesterone receptor protein were present in these tumors in detectable amounts. Ultrastructural features of these granular cell tumors in the breast are similar to those described for extramammary granular cell tumors. These studies agree with previous data that suggest a neurogenic origin for granular cell tumors.

Duke Scholars

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

November 1984

Volume

108

Issue

11

Start / End Page

897 / 901

Location

United States

Related Subject Headings

  • Tissue Distribution
  • S100 Proteins
  • Receptors, Steroid
  • Pathology
  • Neoplasms, Muscle Tissue
  • Myoglobin
  • Microscopy, Electron
  • Male
  • Humans
  • Female
 

Citation

APA
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ICMJE
MLA
NLM
Ingram, D. L., Mossler, J. A., Snowhite, J., Leight, G. S., & McCarty, K. S. (1984). Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein. Arch Pathol Lab Med, 108(11), 897–901.
Ingram, D. L., J. A. Mossler, J. Snowhite, G. S. Leight, and K. S. McCarty. “Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein.Arch Pathol Lab Med 108, no. 11 (November 1984): 897–901.
Ingram DL, Mossler JA, Snowhite J, Leight GS, McCarty KS. Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein. Arch Pathol Lab Med. 1984 Nov;108(11):897–901.
Ingram, D. L., et al. “Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein.Arch Pathol Lab Med, vol. 108, no. 11, Nov. 1984, pp. 897–901.
Ingram DL, Mossler JA, Snowhite J, Leight GS, McCarty KS. Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein. Arch Pathol Lab Med. 1984 Nov;108(11):897–901.

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

November 1984

Volume

108

Issue

11

Start / End Page

897 / 901

Location

United States

Related Subject Headings

  • Tissue Distribution
  • S100 Proteins
  • Receptors, Steroid
  • Pathology
  • Neoplasms, Muscle Tissue
  • Myoglobin
  • Microscopy, Electron
  • Male
  • Humans
  • Female