Infection of normal human thymic epithelial cells by Epstein-Barr virus (EBV) following implantation of EBV receptors.

Published

Journal Article

Normal human thymic epithelial cells cannot be infected and transformed by Epstein-Barr virus (EBV). Measurements using fluorescein-labelled EBV and cytofluorograph revealed that the cells do not have receptors for the virus. Following transplantation of functional EBV receptors onto epithelial cell membranes, however, the cells were infected with EBV and expressed EBV-determined nuclear antigen (EBNA). No EBV associated antigens characteristic of the lytic cycle of the virus were detected. This method of in vitro infection by transforming viruses such as EBV may provide ways of deriving functioning thymic epithelial cell lines.

Full Text

Duke Authors

Cited Authors

  • Seshi, B; Volsky, B; Anderson, RW; Purtilo, DT; Volsky, DJ

Published Date

  • 1984

Published In

Volume / Issue

  • 6 / 1-2

Start / End Page

  • 5 - 13

PubMed ID

  • 6087504

Pubmed Central ID

  • 6087504

International Standard Serial Number (ISSN)

  • 0165-6090

Language

  • eng

Conference Location

  • Netherlands