Response of pulpal blood flow to intra-arterial infusion of endothelin.

Journal Article (Journal Article)

Laser Doppler flowmetry was used to determine the effect of the vasoconstrictor endothelin 1 (ET-1) on the pulpal blood flow of intact dogs' teeth during mandibular arterial infusion. ET-1 produced a profound decrease in pulpal blood flow of a relatively long duration at lower doses than similar infusions of norepinephrine. The decrease in pulpal blood flow in response to ET-1 was partially attenuated by the calcium channel blocker nifedipine. These findings demonstrate the presence of receptors for ET-1 in the microvasculature of the dental pulp and suggests that ET-1 may function in the local control of the pulpal microcirculation.

Full Text

Duke Authors

Cited Authors

  • Gilbert, TM; Pashley, DH; Anderson, RW

Published Date

  • May 1992

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 228 - 231

PubMed ID

  • 1402577

International Standard Serial Number (ISSN)

  • 0099-2399

Digital Object Identifier (DOI)

  • 10.1016/S0099-2399(06)81265-3


  • eng

Conference Location

  • United States