Successful treatment of mediastinal germ cell/endodermal sinus tumors.


Journal Article

Three patients with endodermal sinus tumor of the mediastinum and two with endodermal sinus tumor mixed with other histologies were treated with CEBA (cisplatin, etoposide, bleomycin, and doxorubicin [Adriamycin]) and by cytoreductive surgery. Three patients treated with CEBA followed by surgery achieved a complete remission and remain free of disease at 36+, 35+, and 28+ months, respectively, from diagnosis. Two patients were treated initially with vinblastine, bleomycin, cisplatin, and surgery, and neither achieved a complete remission. Both then received CEBA, and one achieved a complete remission (duration 47 + months). Bone marrow toxicity from CEBA was severe, abrupt, and cumulative. All patients experienced neutropenic fever, anemia, and thrombocytopenia requiring platelet transfusions. The CEBA followed by vigorous cytoreductive surgery is effective treatment for germ cell tumors of the medastinum containing endodermal sinus tumor elements.

Full Text

Duke Authors

Cited Authors

  • Vogelzang, NJ; Anderson, RW; Kennedy, BJ

Published Date

  • July 1, 1985

Published In

Volume / Issue

  • 88 / 1

Start / End Page

  • 64 - 69

PubMed ID

  • 2408824

Pubmed Central ID

  • 2408824

International Standard Serial Number (ISSN)

  • 0012-3692

Digital Object Identifier (DOI)

  • 10.1378/chest.88.1.64


  • eng

Conference Location

  • United States