Modulation of alloreactivity in transplant recipients by phenotypic manipulation of donor endothelium.


Journal Article

Phenotypic manipulation of allograft endothelium to reduce immunogenicity would have a significant impact on transplantation. In this study we have demonstrated that random seeding of a heart allograft with endothelium, of host origin, not only promotes long-term survival, but reduces the requirement for pharmacologic immunosuppression. We propose that this simple technology could easily be extrapolated to the clinical arena where hypothermia and preservation solutions have allowed allografts to remain ex vivo for extended periods.

Full Text

Duke Authors

Cited Authors

  • Quigley, RL; Switzer, SS; Victor, TA; Goldschmidt, RA; Salinger, MH; Arentzen, CE; Alexander, JC; Anderson, RW

Published Date

  • May 1995

Published In

Volume / Issue

  • 109 / 5

Start / End Page

  • 905 - 909

PubMed ID

  • 7739251

Pubmed Central ID

  • 7739251

International Standard Serial Number (ISSN)

  • 0022-5223

Digital Object Identifier (DOI)

  • 10.1016/S0022-5223(95)70315-2


  • eng

Conference Location

  • United States