Lymphocyte abnormalities in preleukemia--I. Decreased NK activity, anomalous immunoregulatory cell subsets and deficient EBV receptors.


Journal Article

The development of acute non-lymphocytic leukemia is preceded by a set of symptoms described as the preleukemia syndrome. Six patients who fulfilled the criteria for this preleukemia syndrome have been evaluated for abnormalities in the lymphocyte population. The NK cell activity was reduced, the immunoregulatory cell populations were numerically abnormal, and the B cell subpopulation was deficient in EBV receptors. Thus, in addition to the abnormalities in the myeloid populations, there are serious defects in the lymphoid systems of preleukemic patients.

Full Text

Duke Authors

Cited Authors

  • Anderson, RW; Volsky, DJ; Greenberg, B; Knox, SJ; Bechtold, T; Kuszynski, C; Harada, S; Purtilo, DT

Published Date

  • 1983

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 389 - 395

PubMed ID

  • 6310273

Pubmed Central ID

  • 6310273

International Standard Serial Number (ISSN)

  • 0145-2126

Digital Object Identifier (DOI)

  • 10.1016/0145-2126(83)90103-0


  • eng

Conference Location

  • England