Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomono phosphate as a potential thymidylate synthase inhibitor.

Journal Article

The 5-ethynyl-2'-deoxyuridine nucleoside and the 5'-boranomonophosphate nucleotide were synthesized as analogs of 5-fluoro-2'-deoxyuridine monophosphate (5-FdUMP), a widely used mechanism-based inhibitor of thymidylate synthase. Synthesis was carried out from protected 5-iodo-2'-deoxyuridine and trimethylsilylacetylene by Sonogashira palladium-catalyzed cross coupling reaction followed by selective phosphorylation and finally boronation.

Full Text

Duke Authors

Cited Authors

  • Khan, SI; Dobrikov, MI; Shaw, BR

Published Date

  • 2005

Published In

Volume / Issue

  • 24 / 5-7

Start / End Page

  • 1047 - 1049

PubMed ID

  • 16248089

International Standard Serial Number (ISSN)

  • 1525-7770

Language

  • eng

Conference Location

  • United States