Positive patches and negative noodles: linking RNA processing to transcription?

Journal Article (Journal Article)

A speculative model is presented that proposes specific mechanisms for effecting co-transcriptional splice site selection in pre-mRNAs. The model envisions that certain splicing factors containing arginine-rich, positively charged regions bind via these positive patches to the hyperphosphorylated, negatively charged tail of elongating RNA polymerase II. Thus tethered to the transcription machinery, these splicing factors gain access to signals in nascent transcripts as they emerge from the polymerase.

Full Text

Duke Authors

Cited Authors

  • Greenleaf, AL

Published Date

  • April 1993

Published In

Volume / Issue

  • 18 / 4

Start / End Page

  • 117 - 119

PubMed ID

  • 8493720

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/0968-0004(93)90016-g


  • eng

Conference Location

  • England