Positive patches and negative noodles: linking RNA processing to transcription?
Publication
, Journal Article
Greenleaf, AL
Published in: Trends Biochem Sci
April 1993
A speculative model is presented that proposes specific mechanisms for effecting co-transcriptional splice site selection in pre-mRNAs. The model envisions that certain splicing factors containing arginine-rich, positively charged regions bind via these positive patches to the hyperphosphorylated, negatively charged tail of elongating RNA polymerase II. Thus tethered to the transcription machinery, these splicing factors gain access to signals in nascent transcripts as they emerge from the polymerase.
Duke Scholars
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
April 1993
Volume
18
Issue
4
Start / End Page
117 / 119
Location
England
Related Subject Headings
- Transcription, Genetic
- Repetitive Sequences, Nucleic Acid
- RNA Splicing
- RNA Precursors
- RNA Polymerase II
- Peptide Fragments
- Molecular Sequence Data
- Models, Genetic
- Developmental Biology
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Greenleaf, A. L. (1993). Positive patches and negative noodles: linking RNA processing to transcription? Trends Biochem Sci, 18(4), 117–119. https://doi.org/10.1016/0968-0004(93)90016-g
Greenleaf, A. L. “Positive patches and negative noodles: linking RNA processing to transcription?” Trends Biochem Sci 18, no. 4 (April 1993): 117–19. https://doi.org/10.1016/0968-0004(93)90016-g.
Greenleaf AL. Positive patches and negative noodles: linking RNA processing to transcription? Trends Biochem Sci. 1993 Apr;18(4):117–9.
Greenleaf, A. L. “Positive patches and negative noodles: linking RNA processing to transcription?” Trends Biochem Sci, vol. 18, no. 4, Apr. 1993, pp. 117–19. Pubmed, doi:10.1016/0968-0004(93)90016-g.
Greenleaf AL. Positive patches and negative noodles: linking RNA processing to transcription? Trends Biochem Sci. 1993 Apr;18(4):117–119.
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
April 1993
Volume
18
Issue
4
Start / End Page
117 / 119
Location
England
Related Subject Headings
- Transcription, Genetic
- Repetitive Sequences, Nucleic Acid
- RNA Splicing
- RNA Precursors
- RNA Polymerase II
- Peptide Fragments
- Molecular Sequence Data
- Models, Genetic
- Developmental Biology
- Animals