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Positive patches and negative noodles: linking RNA processing to transcription?

Publication ,  Journal Article
Greenleaf, AL
Published in: Trends Biochem Sci
April 1993

A speculative model is presented that proposes specific mechanisms for effecting co-transcriptional splice site selection in pre-mRNAs. The model envisions that certain splicing factors containing arginine-rich, positively charged regions bind via these positive patches to the hyperphosphorylated, negatively charged tail of elongating RNA polymerase II. Thus tethered to the transcription machinery, these splicing factors gain access to signals in nascent transcripts as they emerge from the polymerase.

Duke Scholars

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

April 1993

Volume

18

Issue

4

Start / End Page

117 / 119

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Repetitive Sequences, Nucleic Acid
  • RNA Splicing
  • RNA Precursors
  • RNA Polymerase II
  • Peptide Fragments
  • Molecular Sequence Data
  • Models, Genetic
  • Developmental Biology
  • Animals
 

Citation

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MLA
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Greenleaf, A. L. (1993). Positive patches and negative noodles: linking RNA processing to transcription? Trends Biochem Sci, 18(4), 117–119. https://doi.org/10.1016/0968-0004(93)90016-g
Greenleaf, A. L. “Positive patches and negative noodles: linking RNA processing to transcription?Trends Biochem Sci 18, no. 4 (April 1993): 117–19. https://doi.org/10.1016/0968-0004(93)90016-g.
Greenleaf AL. Positive patches and negative noodles: linking RNA processing to transcription? Trends Biochem Sci. 1993 Apr;18(4):117–9.
Greenleaf, A. L. “Positive patches and negative noodles: linking RNA processing to transcription?Trends Biochem Sci, vol. 18, no. 4, Apr. 1993, pp. 117–19. Pubmed, doi:10.1016/0968-0004(93)90016-g.
Greenleaf AL. Positive patches and negative noodles: linking RNA processing to transcription? Trends Biochem Sci. 1993 Apr;18(4):117–119.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

April 1993

Volume

18

Issue

4

Start / End Page

117 / 119

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Repetitive Sequences, Nucleic Acid
  • RNA Splicing
  • RNA Precursors
  • RNA Polymerase II
  • Peptide Fragments
  • Molecular Sequence Data
  • Models, Genetic
  • Developmental Biology
  • Animals