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A nonparametric Bayesian modeling approach for cytogenetic dosimetry.

Publication ,  Journal Article
Kottas, A; Branco, MD; Gelfand, AE
Published in: Biometrics
September 2002

In cytogenetic dosimetry, samples of cell cultures are exposed to a range of doses of a given agent. In each sample at each dose level, some measure of cell disability is recorded. The objective is to develop models that explain cell response to dose. Such models can be used to predict response at unobserved doses. More important, such models can provide inference for unknown exposure doses given the observed responses. Typically, cell disability is viewed as a Poisson count, but in the present work, a more appropriate response is a categorical classification. In the literature, modeling in this case is very limited. What exists is purely parametric. We propose a fully Bayesian nonparametric approach to this problem. We offer comparison with a parametric model through a simulation study and the analysis of a real dataset modeling blood cultures exposed to radiation where classification is with regard to number of micronuclei per cell.

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Published In

Biometrics

DOI

EISSN

1541-0420

ISSN

0006-341X

Publication Date

September 2002

Volume

58

Issue

3

Start / End Page

593 / 600

Related Subject Headings

  • Statistics, Nonparametric
  • Statistics & Probability
  • Micronucleus Tests
  • In Vitro Techniques
  • Humans
  • Dose-Response Relationship, Radiation
  • Cytogenetics
  • Blood Cells
  • Biometry
  • Bayes Theorem
 

Citation

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Kottas, A., Branco, M. D., & Gelfand, A. E. (2002). A nonparametric Bayesian modeling approach for cytogenetic dosimetry. Biometrics, 58(3), 593–600. https://doi.org/10.1111/j.0006-341x.2002.00593.x
Kottas, Athanasios, Márcia D. Branco, and Alan E. Gelfand. “A nonparametric Bayesian modeling approach for cytogenetic dosimetry.Biometrics 58, no. 3 (September 2002): 593–600. https://doi.org/10.1111/j.0006-341x.2002.00593.x.
Kottas A, Branco MD, Gelfand AE. A nonparametric Bayesian modeling approach for cytogenetic dosimetry. Biometrics. 2002 Sep;58(3):593–600.
Kottas, Athanasios, et al. “A nonparametric Bayesian modeling approach for cytogenetic dosimetry.Biometrics, vol. 58, no. 3, Sept. 2002, pp. 593–600. Epmc, doi:10.1111/j.0006-341x.2002.00593.x.
Kottas A, Branco MD, Gelfand AE. A nonparametric Bayesian modeling approach for cytogenetic dosimetry. Biometrics. 2002 Sep;58(3):593–600.
Journal cover image

Published In

Biometrics

DOI

EISSN

1541-0420

ISSN

0006-341X

Publication Date

September 2002

Volume

58

Issue

3

Start / End Page

593 / 600

Related Subject Headings

  • Statistics, Nonparametric
  • Statistics & Probability
  • Micronucleus Tests
  • In Vitro Techniques
  • Humans
  • Dose-Response Relationship, Radiation
  • Cytogenetics
  • Blood Cells
  • Biometry
  • Bayes Theorem