Ornithine aminotransferase-related sequences map to two nonadjacent intervals on the human X chromosome short arm.


Journal Article

Using a panel of human/rodent somatic cell hybrids segregating human X/autosome translocations and deletions, we have refined the localization of the X-linked sequences homologous to ornithine-delta-aminotransferase (OAT), the structural locus for which (OAT) maps to chromosome 10. OAT-related ("-like") (OATL) sequences mapped to two nonadjacent intervals: OATL1 mapped to Xp11.3-p11.23, while OATL2 mapped to Xp11.22-p11.21. X-linked OATL1 sequences polymorphic for ScaI and StuI map to the more distal interval in Xp11.3-p11.23. These results should help guide long-range cloning and mapping studies, as well as refine the genetic linkage map in this region of the X chromosome.

Full Text

Cited Authors

  • Lafreniere, RG; Geraghty, MT; Valle, D; Shows, TB; Willard, HF

Published Date

  • May 1991

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 276 - 279

PubMed ID

  • 1675195

Pubmed Central ID

  • 1675195

Electronic International Standard Serial Number (EISSN)

  • 1089-8646

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(91)90512-d


  • eng