Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome.


Journal Article

S100 protein is a calcium-binding protein found predominantly in the vertebrate nervous system. Genomic and complementary DNA probes were used in conjunction with a panel of rodent-human somatic cell hybrids to assign the gene for the beta subunit of S100 protein to the distal half of the long arm of human chromosome 21. This gene was identified as a candidate sequence which, when expressed in the trisomic state, may underlie the neurologic disturbances in Down syndrome.

Full Text

Cited Authors

  • Allore, R; O'Hanlon, D; Price, R; Neilson, K; Willard, HF; Cox, DR; Marks, A; Dunn, RJ

Published Date

  • March 1988

Published In

Volume / Issue

  • 239 / 4845

Start / End Page

  • 1311 - 1313

PubMed ID

  • 2964086

Pubmed Central ID

  • 2964086

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2964086


  • eng