Centromeres of mammalian chromosomes.


Journal Article (Review)

The centromere is the major cis-acting genetic locus involved in chromosome segregation in mitosis and meiosis. The mammalian centromere is characterized by large amounts of tandemly repeated satellite DNA and by a number of specific centromere proteins, at least one of which has been shown to interact directly with centromeric satellite DNA sequences. Although direct functional assays of chromosome segregation are still lacking, the data are most consistent with a structural and possibly functional role for satellite DNA in the mammalian centromere.

Full Text

Cited Authors

  • Willard, HF

Published Date

  • December 1990

Published In

Volume / Issue

  • 6 / 12

Start / End Page

  • 410 - 416

PubMed ID

  • 2087784

Pubmed Central ID

  • 2087784

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/0168-9525(90)90302-m


  • eng