The 56/58 kDa androgen-binding protein in male genital skin fibroblasts with a deleted androgen receptor gene.

Published

Journal Article

Human genital skin fibroblasts (GSF) make a relatively abundant 56/58 kDa protein that binds androgens. The protein shares many properties with the approximately 100 kDa androgen receptor that is encoded by a locus in the q12 region of the X chromosome. It does not appear to be androgen-induced, yet is absent in GSF of most patients with complete androgen insensitivity (CAI). A precursor-product relation with the androgen receptor (AR) protein has been largely excluded; that it may be an unorthodox product of the AR gene has not. The 56/58 kDa protein is made by the GSF of a mentally retarded subject who has CAI because of a complete deletion of the coding portion of the AR gene. Hence, the strong constitutional and statistical correlations that have been demonstrated between the two proteins cannot arise because they share the same gene. The subject's genomic DNA hybridizes normally with 11 single-copy probes from Xq11-Xq13. Therefore, we cannot attribute her mental retardation to a contiguous gene syndrome.

Full Text

Cited Authors

  • Trifiro, M; Gottlieb, B; Pinsky, L; Kaufman, M; Prior, L; Belsham, DD; Wrogemann, K; Brown, CJ; Willard, HF; Trapman, J

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 75 / 1

Start / End Page

  • 37 - 47

PubMed ID

  • 2050265

Pubmed Central ID

  • 2050265

Electronic International Standard Serial Number (EISSN)

  • 1872-8057

International Standard Serial Number (ISSN)

  • 0303-7207

Digital Object Identifier (DOI)

  • 10.1016/0303-7207(91)90243-l

Language

  • eng