Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.


Journal Article

The gene for the androgen receptor, mutations at which cause the X-linked androgen insensitivity syndrome, has been localized to the q11----q12 region of the human X chromosome by analysis, using a cloned cDNA for the androgen receptor, of somatic cell hybrid panels segregating portions of the X chromosome. A moderate-frequency HindIII RFLP has been found which should be useful in genetic linkage analysis of the various inherited forms of androgen insensitivity.

Full Text

Cited Authors

  • Brown, CJ; Goss, SJ; Lubahn, DB; Joseph, DR; Wilson, EM; French, FS; Willard, HF

Published Date

  • February 1989

Published In

Volume / Issue

  • 44 / 2

Start / End Page

  • 264 - 269

PubMed ID

  • 2563196

Pubmed Central ID

  • 2563196

Electronic International Standard Serial Number (EISSN)

  • 1537-6605

International Standard Serial Number (ISSN)

  • 0002-9297


  • eng