Molecular characterization of isochromosomes of Xq.


Journal Article

We have undertaken a study of 35 patients with i(Xq) to determine whether those that are maternally derived originate by similar mechanisms to those that are paternally derived. Isochromosome formation is not associated with increased parental age and > 90% of i(Xq) contain proximal Xp sequences suggesting that centromere misdivision is not a common mechanism of formation. Our results indicate that the majority of i(Xq) originate from a single X chromosome and the usual mechanisms of formation do not appear to differ according to the parent of origin.

Full Text

Cited Authors

  • James, RS; Dalton, P; Gustashaw, K; Wolff, DJ; Willard, HF; Mitchell, C; Jacobs, PA

Published Date

  • November 1997

Published In

Volume / Issue

  • 61 / Pt 6

Start / End Page

  • 485 - 490

PubMed ID

  • 9543548

Pubmed Central ID

  • 9543548

Electronic International Standard Serial Number (EISSN)

  • 1469-1809

International Standard Serial Number (ISSN)

  • 0003-4800

Digital Object Identifier (DOI)

  • 10.1046/j.1469-1809.1997.6160485.x


  • eng