Localization of the X inactivation centre on the human X chromosome in Xq13.


Journal Article

X-chromosome inactivation results in the strictly cis-limited inactivation of many but not all genes on one of the two X chromosomes during early development in somatic cells of mammalian females. One feature of virtually all models of X inactivation is the existence of an X-inactivation centre (XIC) required in cis for inactivation to occur. This concept predicts that all structurally abnormal X chromosomes capable of being inactivated have in common a defineable region of the X chromosome. Here we report an analysis of several such rearranged human X chromosomes and define a minimal region of overlap. The results are consistent with models invoking a single XIC and provide a molecular foothold for cloning and analysing the XIC region. One of the markers that defines this region is the XIST gene, which is expressed specifically from inactive, but not active, X chromosomes. The localization of the XIST gene to the XIC region on the human X chromosome implicates XIST in some aspect of X inactivation.

Full Text

Cited Authors

  • Brown, CJ; Lafreniere, RG; Powers, VE; Sebastio, G; Ballabio, A; Pettigrew, AL; Ledbetter, DH; Levy, E; Craig, IW; Willard, HF

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 349 / 6304

Start / End Page

  • 82 - 84

PubMed ID

  • 1985270

Pubmed Central ID

  • 1985270

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/349082a0


  • eng