Chromosomal location of human P-glycoprotein gene sequences.


Journal Article

Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.

Full Text

Cited Authors

  • Bell, DR; Trent, JM; Willard, HF; Riordan, JR; Ling, V

Published Date

  • March 1, 1987

Published In

Volume / Issue

  • 25 / 1

Start / End Page

  • 141 - 148

PubMed ID

  • 2879621

Pubmed Central ID

  • 2879621

Electronic International Standard Serial Number (EISSN)

  • 1873-4456

International Standard Serial Number (ISSN)

  • 0165-4608

Digital Object Identifier (DOI)

  • 10.1016/0165-4608(87)90169-5


  • eng