A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome.


Journal Article

X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern--transcripts are detected only from the inactive X chromosome (Xi) and not from the active X chromosome (Xa). This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation.

Full Text

Cited Authors

  • Brown, CJ; Ballabio, A; Rupert, JL; Lafreniere, RG; Grompe, M; Tonlorenzi, R; Willard, HF

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 349 / 6304

Start / End Page

  • 38 - 44

PubMed ID

  • 1985261

Pubmed Central ID

  • 1985261

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/349038a0


  • eng