Mapping DNA sequences in a human X-chromosome deletion which extends across the region of the Duchenne muscular dystrophy mutation.

Published

Journal Article

A somatic cell hybrid has been constructed and characterized using fibroblasts from a phenotypically normal woman who possesses an X chromosome with an interstitial deletion of the short arm. High-resolution banding indicates that the deleted segment is either Xp22.13-p11.4 or Xp22.11-p11.23. Southern blot hybridization to previously mapped DNA sequences confirms that the missing segment of the X chromosome is a deletion and not an interstitial translocation and supports the cytogenetic interpretation that the deletion extends proximal of Xp11.3 and therefore probably comprises Xp22.11-p11.23. Three further DNA sequences have been localized to the region of the deleted segment. The following order has been assigned to the seven probes used: Xpter-RC8-pXUT22-(OA1,C7,M2C)-L1.28-RD6 -Xcen.

Full Text

Cited Authors

  • Ingle, C; Williamson, R; de la Chapelle, A; Herva, RR; Haapala, K; Bates, G; Willard, HF; Pearson, P; Davies, KE

Published Date

  • May 1, 1985

Published In

Volume / Issue

  • 37 / 3

Start / End Page

  • 451 - 462

PubMed ID

  • 2988331

Pubmed Central ID

  • 2988331

Electronic International Standard Serial Number (EISSN)

  • 1537-6605

International Standard Serial Number (ISSN)

  • 0002-9297

Language

  • eng