Physical mapping of 60 DNA markers in the p21.1----q21.3 region of the human X chromosome.


Journal Article

Using a panel of human/rodent somatic cell hybrids and human lymphoblast lines segregating 18 different human X-chromosome rearrangements and deletions, we have assigned 60 DNA markers to the physical map of the X chromosome from Xp21.1 to Xq21.3. Data from Southern blot hybridization and polymerase chain reaction (PCR) amplification assign these markers to 15 primary map intervals. This provides a basis for further long-range cloning and mapping of the pericentromeric region of the X chromosome.

Full Text

Cited Authors

  • Lafrenière, RG; Brown, CJ; Powers, VE; Carrel, L; Davies, KE; Barker, DF; Willard, HF

Published Date

  • October 1991

Published In

Volume / Issue

  • 11 / 2

Start / End Page

  • 352 - 363

PubMed ID

  • 1685139

Pubmed Central ID

  • 1685139

Electronic International Standard Serial Number (EISSN)

  • 1089-8646

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(91)90143-3


  • eng