The UTX gene escapes X inactivation in mice and humans.

Published

Journal Article

We recently have identified a ubiquitously transcribed mouse Y chromosome gene, Uty , which encodes a tetratricopeptide repeat (TPR) protein. A peptide derived from the UTY protein confers H-Y antigenicity on male cells. Here we report the characterization of a widely transcribed X-linked homologue of Uty , called Utx , which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11.2. Given that Uty is ubiquitously transcribed, we assayed for Utx expression from the inactive X chromosome (Xi) in mice and found that Utx escapes X chromosome inactivation. Only Smcx and the pseudoautosomal Sts gene on the mouse X chromosome have been reported previously to escape inactivation. The human UTX gene was also found to be expressed from Xi. We discuss the significance of these data for our understanding of dosage compensation of X-Y homologous genes in humans and mice.

Full Text

Cited Authors

  • Greenfield, A; Carrel, L; Pennisi, D; Philippe, C; Quaderi, N; Siggers, P; Steiner, K; Tam, PP; Monaco, AP; Willard, HF; Koopman, P

Published Date

  • April 1998

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 737 - 742

PubMed ID

  • 9499428

Pubmed Central ID

  • 9499428

Electronic International Standard Serial Number (EISSN)

  • 1460-2083

International Standard Serial Number (ISSN)

  • 0964-6906

Digital Object Identifier (DOI)

  • 10.1093/hmg/7.4.737

Language

  • eng