Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene.


Journal Article

To understand how gene expression patterns are established on the inactive X chromosome during development, we have studied the murine gene Smcx, which is expressed from both the active and inactive mouse X chromosomes. In all tissues assayed, Smcx only partially escapes X inactivation, with expression levels from the inactive X allele approximately 30-65% that of the active X allele. Additionally, inactive X expression levels differed between extraembryonic and embryonic tissues and among different tissues from newborn and adult mice. Imprinted extraembryonic tissue had the lowest levels of inactive X Smcx expression, whereas the highest levels were in heart. These data suggest that the chromosomal basis of X inactivation differs among tissues, perhaps reflecting differences in the timing or regulation of inactivation in these cell lineages.

Full Text

Cited Authors

  • Carrel, L; Hunt, PA; Willard, HF

Published Date

  • September 1996

Published In

Volume / Issue

  • 5 / 9

Start / End Page

  • 1361 - 1366

PubMed ID

  • 8872478

Pubmed Central ID

  • 8872478

Electronic International Standard Serial Number (EISSN)

  • 1460-2083

International Standard Serial Number (ISSN)

  • 0964-6906

Digital Object Identifier (DOI)

  • 10.1093/hmg/5.9.1361


  • eng